Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile

Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile

Abstract Glioblastoma is one of the most treatment-resistant and lethal cancers, with a subset of self-renewing brain tumour stem cells (BTSCs), driving therapy resistance and relapse. Here, we report that mubritinib effectively impairs BTSC stemness and growth. Mechanistically, bioenergetic assays...

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Main Authors: Audrey Burban, Cloe Tessier, Mathieu Larroquette, Joris Guyon, Cloe Lubiato, Mathis Pinglaut, Maxime Toujas, Johanna Galvis, Benjamin Dartigues, Emmanuelle Georget, H Artee Luchman, Samuel Weiss, David Cappellen, Nathalie Nicot, Barbara Klink, Macha Nikolski, Lucie Brisson, Thomas Mathivet, Andreas Bikfalvi, Thomas Daubon, Ahmad Sharanek
Format: Article
Language:English
Published: Springer Nature 2025-02-01
Series:EMBO Molecular Medicine
Subjects:
Metabolic Reliance
Oxidative Phosphorylation
Radiotherapy
Hypoxia
Reactive Oxygen Species
Online Access:https://doi.org/10.1038/s44321-025-00195-6
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https://doi.org/10.1038/s44321-025-00195-6

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