Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management

Dipeptidyl peptidase-4 enzyme inhibition and its impacts on hepatic preneoplasia: a new avenue for liver cancer management

AimsDipeptidyl peptidase-4 enzyme (DPP-4) was reported to be associated with immune stimulation, resistance to anti-neoplastic agents and lipid accumulation. Dysregulated DPP-4 expression was reported in various malignant tumors such as hepatocellular carcinoma. Hence, the influence of sitagliptin,...

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Main Authors: Hebatollah E. Eitah, Rabab H. Sayed, Yousreya A. Maklad, Amina A. Gamal el Din, Khaled Mahmoud, Ayman E. El-Sahar, Amani Alhejely, Amal A. Abdulbaqi, Hanan Naeim Attia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
Subjects:
CYP2E1
CYP3A4
diethylnitrosamine
DPP-4
hepatic preneoplasia
sitagliptin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1559303/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1559303/full

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