Management strategies for CAR-T cell therapy-related toxicities: results from a survey in Greece

Management strategies for CAR-T cell therapy-related toxicities: results from a survey in Greece

Chimeric antigen receptor T-cell (CAR-T) therapy has transformed the management of relapsed or refractory hematologic malignancies, offering remarkable remission rates. However, severe toxicities, including cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (I...

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Main Authors: Eleni Gavriilaki, Ifigeneia Tzannou, Anna Vardi, Ioannis Tsonis, Maria Liga, Konstantinos Gkirkas, Maria Ximeri, Zoi Bousiou, Maria Bouzani, Eleftheria Sagiadinou, Panagiotis Dolgyras, Nikolaos Kotsiou, Vasiliki Bampali, Despina Mallouri, Tatiana Tzenou, Ioannis Batsis, Damianos Sotiropoulos, Stavros Gigantes, Helen A. Papadaki, Panagiotis Tsirigotis, Alexandros Spyridonidis, Theodoros P. Vassilakopoulos, Maria Angelopoulou, Ioannis Baltadakis, Ioanna Sakellari
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Medicine
Subjects:
CAR-T cells
axicabtagene ciloleucel (axi-cel)
tisagenlecleucel (tisa-cel)
brexucabtagene autoleucel (brexu-cel)
cytokine release syndrome (CRS)
immune effector-cell-associated neurotoxicity syndrome (ICANS)
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1553966/full
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https://www.frontiersin.org/articles/10.3389/fmed.2025.1553966/full

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