Plasmodium falciparum reticulocyte-binding homologues are targets of human inhibitory antibodies and play a role in immune evasion

Plasmodium falciparum reticulocyte-binding homologues are targets of human inhibitory antibodies and play a role in immune evasion

IntroductionAntibodies targeting the blood-stage of Plasmodium falciparum play a critical role in naturally acquired immunity to malaria by limiting blood-stage parasitemia. One mode of action of antibodies is the direct inhibition of merozoite invasion of erythrocytes through targeting invasion lig...

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Bibliographic Details
Main Authors: Linda Reiling, Kristina E. M. Persson, Fiona J. McCallum, Nimmo Gicheru, Samson M. Kinyanjui, Chetan E. Chitnis, Freya J. I. Fowkes, Kevin Marsh, James G. Beeson
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
P. falciparum
inhibitory antibodies
phenotypic variation
immune evasion
reticulocyte binding homologues
RH proteins
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532451/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1532451/full

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