Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues

Abstract Essential transcription and cell cycle progression controllers are CDKs, whose dysregulation is a defining trait of many human cancers. CDKs have grown to be very crucial therapeutic targets in cancer. Although traditional CDK inhibitors have demonstrated therapeutic efficacy, they frequent...

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Bibliographic Details
Main Authors: Hany E. Marei, Khaled Bedair, Anwarul Hasan, Layla Al-Mansoori, Alice Gaiba, Andrea Morrione, Carlo Cenciarelli, Antonio Giordano
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00931-8
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