Impact of Reduction in Myeloid‐derived Suppressor Cells by Wilms’ Tumor 1‐targeted Dendritic Cell Vaccines on Clinical Outcomes in Acute Leukemia Patients

Impact of Reduction in Myeloid‐derived Suppressor Cells by Wilms’ Tumor 1‐targeted Dendritic Cell Vaccines on Clinical Outcomes in Acute Leukemia Patients

ABSTRACT Background Myeloid‐derived suppressor cells (MDSCs) play a critical role in immunotherapy. Methods We investigated the effects of the Wilms' tumor 1 (WT1) peptide‐loaded dendritic cell (DC) vaccination on MDSCs in patients with acute leukemia. Results WT1‐DC vaccination reduced MDSCs a...

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Bibliographic Details
Main Authors: Masahiro Ogasawara, Mamiko Miyashita, Yuka Yamagishi, Shuichi Ota
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:eJHaem
Subjects:
acute leukemia
dendritic cell vaccine
myeloid‐derived suppressor cells
Wilms' tumor 1
Online Access:https://doi.org/10.1002/jha2.70048
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https://doi.org/10.1002/jha2.70048

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