Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity

Bioinformatic and genomic analysis identifies C allele of APOE rs7412 as the most prominent variant limiting extreme human longevity

Abstract The genetic factors influencing human longevity have long been a subject of curiosity, linking ancient historical records with modern genomic research. This study seeks to identify key genetic contributors to lifespan by integrating genome-wide association studies (GWAS) with functional ann...

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Main Authors: Rahmat Dani Satria, Usi Sukorini, Mohammad Hendra Setia Lesmana, Lalu Muhammad Irham, Wirawan Adikusuma, Hegaria Rahmawati, Nur Imma Fatimah Harahap, Pranindya Rinastiti, Donytra Arby Wardhana, Osman Sianipar, Gisca Ajeng Widya Ninggar, Zaenal Muttaqien Sofro, Nova Yuli Prasetyo Budi, Josephine Diony Nanda, Faizul Hasan, Tri Budi W. Rahardjo, Chiou-Feng Lin
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Longevity
APOE
SNP
Bioinformatics
GWAS
Online Access:https://doi.org/10.1038/s41598-025-02848-5
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https://doi.org/10.1038/s41598-025-02848-5

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