Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer

Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer

Abstract Background Lung cancer remains a leading cancer type, but current chemotherapy is limited by issues including poor drug delivery, toxicity, and resistance. To address these challenges, we developed a novel PLGA-PEG-LHRH (PPL) nanoconjugate system for improved drug delivery. Curcumin, known...

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Main Authors: Madhuchandra Lahan, Trideep Saikia, Kalpajit Dutta, Rinku Baishya, Alakesh Bharali, Sunayana Baruah, Rituraj Bharadwaj, Subhash Medhi, Bhanu P. Sahu
Format: Article
Language:English
Published: SpringerOpen 2024-11-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Lung cancer
Targeted delivery
Curcumin
Drug resistance
Nanoconjugates
Online Access:https://doi.org/10.1186/s43094-024-00743-w
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https://doi.org/10.1186/s43094-024-00743-w

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