Analytical validation of Aspyre Clinical Test for Lung (Blood): A multiplexed PCR and pyrophosphorolysis-based assay for detecting actionable NSCLC variants in plasma cfDNA and cfRNA

Analytical validation of Aspyre Clinical Test for Lung (Blood): A multiplexed PCR and pyrophosphorolysis-based assay for detecting actionable NSCLC variants in plasma cfDNA and cfRNA

Background: Liquid biopsy is an important non-invasive method of sampling the molecular profile of tumors for patients to access personalized oncology therapeutics but can be challenging. NGS-based methods require high sample quality, high sequencing depth and associated cost, with complex workflows...

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Main Authors: Ryan Thomas Evans, Katherine Elizabeth Knudsen, Elizabeth Gillon-Zhang, Julia Natalie Brown, Candace King, Mary Beth Rossi, Cory Kiser, James Alexander Schaffernoth, Amanda Shull Green, Ana-Luisa Silva, Kristine von Bargen, Justyna Malgorzata Mordaka, Rebecca Natalie Palmer, Alessandro Tomassini, Alejandra Collazos, Simonetta Andreazza, Iyelola Turner, Chau Ha Ho, Dilyara Nugent, Jinsy Jose, Christina Xyrafaki, Prarthna Barot, Magdalena Stolarek-Januszkiewicz, Sam Abujudeh, Eleanor Ruth Gray, Jeffrey Gregg, Wendy Jo Levin, Barnaby William Balmforth, Kelly Pitts, Shari Brown
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:The Journal of Liquid Biopsy
Subjects:
Analytical validation
Liquid biopsy
NSCLC
Molecular profiling
Online Access:http://www.sciencedirect.com/science/article/pii/S2950195425000141
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