Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria
Recently, the diagnostic criteria of preeclampsia have been changed. No studies are available in the literature that analyzed in detail the differences between early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP), taking into account the International Society for the Study of Hypertensio...
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| Format: | Article |
| Language: | English |
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2019-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2019/4108271 |
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| author | Anna Wójtowicz Małgorzata Zembala-Szczerba Dorota Babczyk Monika Kołodziejczyk-Pietruszka Olga Lewaczyńska Hubert Huras |
| author_facet | Anna Wójtowicz Małgorzata Zembala-Szczerba Dorota Babczyk Monika Kołodziejczyk-Pietruszka Olga Lewaczyńska Hubert Huras |
| author_sort | Anna Wójtowicz |
| collection | DOAJ |
| description | Recently, the diagnostic criteria of preeclampsia have been changed. No studies are available in the literature that analyzed in detail the differences between early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP), taking into account the International Society for the Study of Hypertension in Pregnancy (ISSHP) criteria. Thus, we sought to retrospectively investigate in detail the differences in clinical and laboratory outcomes between EOP and LOP diagnosed according to the ISSHP criteria. A retrospective cohort study was conducted in 214 women with singleton pregnancies and preeclampsia admitted to the Department of Obstetrics and Perinatology of the University Hospital in Kraków, Poland, from 2013 to 2017 (113 (52.8%) women with EOP and 101 (47.2%) women with LOP). Electronic medical records were reviewed for demographics and medical history, laboratory tests, and delivery and neonatal data. Patients with preeclampsia accounted for 1.7% of the women who delivered during the study period. The EOP and LOP groups did not differ in the distribution of risk factors for preeclampsia. The most common risk factor was primiparity, which was observed in 72.0% of cases. Regarding the ISSHP diagnostic criteria, the two groups differed in the incidence of fetal growth restriction (p=0.0009), hemolysis (p=0.0416), and neurological complications (p=00342), which were found more often in the EOP group. In addition, the EOP group had more frequent occurrence of severe cardiorespiratory (p<0.0001) and hematological (p=0.0127) complications, adverse fetoplacental conditions (p<0.0001), and severe fetoplacental complications (p=0.0003). Children born to women with EOP had lower Apgar scores (p<0.001) and higher rates of intraventricular hemorrhage (p<0.0001), respiratory disorders requiring mechanical ventilation (p<0.0001), and early (p=0.0004) and late sepsis (p=0.002). EOP differed from LOP in terms of maternal and perinatal adverse outcomes. The observed higher rates of fetoplacental adverse conditions and severe complications indicate a significant contribution of impaired placentation to the etiopathogenesis of EOP. |
| format | Article |
| id | doaj-art-4d38c7b525684f8aa6a6bd28f1cd63ee |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
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| series | International Journal of Hypertension |
| spelling | doaj-art-4d38c7b525684f8aa6a6bd28f1cd63ee2025-02-03T06:10:49ZengWileyInternational Journal of Hypertension2090-03842090-03922019-01-01201910.1155/2019/41082714108271Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP CriteriaAnna Wójtowicz0Małgorzata Zembala-Szczerba1Dorota Babczyk2Monika Kołodziejczyk-Pietruszka3Olga Lewaczyńska4Hubert Huras5Department of Obstetrics & Perinatology, Jagiellonian University Medical College, Ul. Kopernika 23, 31-501 Kraków, PolandDepartment of Obstetrics & Perinatology, Jagiellonian University Medical College, Ul. Kopernika 23, 31-501 Kraków, PolandDepartment of Obstetrics & Perinatology, Jagiellonian University Medical College, Ul. Kopernika 23, 31-501 Kraków, PolandDepartment of Obstetrics & Perinatology, Jagiellonian University Medical College, Ul. Kopernika 23, 31-501 Kraków, PolandDepartment of Neonatology, Jagiellonian University Medical College, Ul. Kopernika 23, 31-501 Kraków, PolandDepartment of Obstetrics & Perinatology, Jagiellonian University Medical College, Ul. Kopernika 23, 31-501 Kraków, PolandRecently, the diagnostic criteria of preeclampsia have been changed. No studies are available in the literature that analyzed in detail the differences between early-onset preeclampsia (EOP) and late-onset preeclampsia (LOP), taking into account the International Society for the Study of Hypertension in Pregnancy (ISSHP) criteria. Thus, we sought to retrospectively investigate in detail the differences in clinical and laboratory outcomes between EOP and LOP diagnosed according to the ISSHP criteria. A retrospective cohort study was conducted in 214 women with singleton pregnancies and preeclampsia admitted to the Department of Obstetrics and Perinatology of the University Hospital in Kraków, Poland, from 2013 to 2017 (113 (52.8%) women with EOP and 101 (47.2%) women with LOP). Electronic medical records were reviewed for demographics and medical history, laboratory tests, and delivery and neonatal data. Patients with preeclampsia accounted for 1.7% of the women who delivered during the study period. The EOP and LOP groups did not differ in the distribution of risk factors for preeclampsia. The most common risk factor was primiparity, which was observed in 72.0% of cases. Regarding the ISSHP diagnostic criteria, the two groups differed in the incidence of fetal growth restriction (p=0.0009), hemolysis (p=0.0416), and neurological complications (p=00342), which were found more often in the EOP group. In addition, the EOP group had more frequent occurrence of severe cardiorespiratory (p<0.0001) and hematological (p=0.0127) complications, adverse fetoplacental conditions (p<0.0001), and severe fetoplacental complications (p=0.0003). Children born to women with EOP had lower Apgar scores (p<0.001) and higher rates of intraventricular hemorrhage (p<0.0001), respiratory disorders requiring mechanical ventilation (p<0.0001), and early (p=0.0004) and late sepsis (p=0.002). EOP differed from LOP in terms of maternal and perinatal adverse outcomes. The observed higher rates of fetoplacental adverse conditions and severe complications indicate a significant contribution of impaired placentation to the etiopathogenesis of EOP.http://dx.doi.org/10.1155/2019/4108271 |
| spellingShingle | Anna Wójtowicz Małgorzata Zembala-Szczerba Dorota Babczyk Monika Kołodziejczyk-Pietruszka Olga Lewaczyńska Hubert Huras Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria International Journal of Hypertension |
| title | Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria |
| title_full | Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria |
| title_fullStr | Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria |
| title_full_unstemmed | Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria |
| title_short | Early- and Late-Onset Preeclampsia: A Comprehensive Cohort Study of Laboratory and Clinical Findings according to the New ISHHP Criteria |
| title_sort | early and late onset preeclampsia a comprehensive cohort study of laboratory and clinical findings according to the new ishhp criteria |
| url | http://dx.doi.org/10.1155/2019/4108271 |
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