RSK1 dependency in FLT3-ITD acute myeloid leukemia

RSK1 dependency in FLT3-ITD acute myeloid leukemia

Abstract Internal tandem duplications (ITD) in fms-like tyrosine kinase 3 (FLT3) represent the most common genetic alteration in de novo acute myeloid leukemia (AML). Here, we identify ribosomal protein s6 kinase a1 (RSK1) as a core dependency in FLT3-ITD AML and unveil the existence of crucial bi-d...

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Main Authors: Tim Kong, Angelo B. A. Laranjeira, Christopher T. Letson, LaYow Yu, Fan He, Aarthi Jayanthan, Gerrit Los, Sandra E. Dunn, Grant A. Challen, Stephen T. Oh
Format: Article
Language:English
Published: Nature Publishing Group 2024-11-01
Series:Blood Cancer Journal
Online Access:https://doi.org/10.1038/s41408-024-01187-4
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https://doi.org/10.1038/s41408-024-01187-4

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