Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Polygenic and pharmacogenomic contributions to medication dosing: a real-world longitudinal biobank study

Abstract Background Understanding interindividual variability in medication dosing is central to precision medicine. Despite significant pharmacogenomic (PGx) insights into key biological pathways influencing drug response, the polygenic contribution to dose variability and the potential of electron...

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Bibliographic Details
Main Authors: Silva Kasela, Laura Birgit Luitva, Kristi Krebs, Estonian Biobank Research Team, Märt Möls, Lili Milani, Maris Alver
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
Real-world health data
Electronic Health Records
Biobank
Medication dosing
Pharmacogenomics
Genome-wide association study
Online Access:https://doi.org/10.1186/s12967-025-06782-y
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https://doi.org/10.1186/s12967-025-06782-y

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