Genetic effects of circulating hormone and proteome on amyotrophic lateral sclerosis identified by Mendelian randomization

Genetic effects of circulating hormone and proteome on amyotrophic lateral sclerosis identified by Mendelian randomization

Abstract Altered circulating hormones in ALS patients have been widely reported by previous observational studies, but whether these relationships are causal is unclear. Moreover, the potential therapeutic targets for ALS and the effects of plasma protein fluctuation on ALS progression are not fully...

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Main Authors: Xinyue Fan, Yinting Zeng, Feifei Zhang, Yang Xu, Qixuan Duan, Shuting Long, Yumeng Lin, Kai Wang, Li Jiang
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Amyotrophic lateral sclerosis
Hormone
Free testosterone
Proteome
Cytokine
Inflammation
Online Access:https://doi.org/10.1038/s41598-025-95151-2
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https://doi.org/10.1038/s41598-025-95151-2

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