The downregulation of hormone-sensitive lipase and dysregulation of cholesterol receptors/transporter affect testicular lipid homeostasis and function in HFD-induced oligoasthenospermia mice

Abstract Background Obesity-induced oligoasthenospermia is associated with testicular lipid metabolism. However, the mechanisms underlying the lipid homeostasis imbalance of obesity-induced oligoasthenospermia are unclear. Methods Male C57BL/6 mice fed a high-fat diet were established for the in viv...

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Bibliographic Details
Main Authors: Min Pan, Jingya Li, Yujia Wang, Ziao Liu, Li Li, Tongsheng Wang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Molecular Medicine
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Online Access:https://doi.org/10.1186/s10020-025-01327-x
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