Bitter lemon extract mitigates obesity-exacerbated osteoarthritis by suppressing Mmp-13 and restoring redox balance through Nrf2/Ho-1 upregulation

Bitter lemon extract mitigates obesity-exacerbated osteoarthritis by suppressing Mmp-13 and restoring redox balance through Nrf2/Ho-1 upregulation

Abstract Background Osteoarthritis, the most common joint disease, affects over 500 million people globally, especially the elderly. Due to the increasing aging population and obesity rate, obesity is expected to increase over time, making it a significant public health challenge. This study investi...

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Main Authors: Ayodeji Johnson Ajibare, Olabode Oluwadare Akintoye, Oluwatobiloba Adesewa Oriowo, Abosede Mary Ayoola, Isaac Adeola Oriyomi, Joshua Favour Adedara, Favour Oluwaferanmi Oluwamoroti, Kehinde Olaniyi, Kayode Tajudeen Salami
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Osteoarthritis
Obesity
Inflammation
Adipokines
Oxidative stress
Online Access:https://doi.org/10.1186/s43094-025-00845-z
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https://doi.org/10.1186/s43094-025-00845-z

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