Polymer model integrates imaging and sequencing to reveal how nanoscale heterochromatin domains influence gene expression

Abstract Chromatin organization regulates gene expression, with nanoscale heterochromatin domains playing a fundamental role. Their size varies with microenvironmental stiffness and epigenetic interventions, but how these factors regulate their formation and influence transcription remains unclear....

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Bibliographic Details
Main Authors: Vinayak Vinayak, Ramin Basir, Rosela Golloshi, Joshua Toth, Lucas Sant’Anna, Melike Lakadamyali, Rachel Patton McCord, Vivek B. Shenoy
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59001-z
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