Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters
Abstract Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone density and fragility, impairing quality of life. Traditional treatments often overlook symptoms like back and joint pain, increasing burden. This study aims to map relationships between natural medicines, targets,...
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Nature Portfolio
2025-03-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-95304-3 |
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| author | Yili Zhang Xiangyun Guo Kai Sun Liang Wang Siyuan Huang Yiwen Gan Jinran Qin Qingqing Liu Yan Li Zikai Jin Liguo Zhu Xu Wei |
| author_facet | Yili Zhang Xiangyun Guo Kai Sun Liang Wang Siyuan Huang Yiwen Gan Jinran Qin Qingqing Liu Yan Li Zikai Jin Liguo Zhu Xu Wei |
| author_sort | Yili Zhang |
| collection | DOAJ |
| description | Abstract Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone density and fragility, impairing quality of life. Traditional treatments often overlook symptoms like back and joint pain, increasing burden. This study aims to map relationships between natural medicines, targets, and symptom clusters, demonstrating their effectiveness in personalized OP treatment to enhance clinical strategies and self-assessment. We used compounds and targets, applying Summary data-based Mendelian Randomisation (SMR) analysis for biological process and molecular function enrichment. Additionally, we employed Phenome-Wide Association Studies (PheWAS) to select two natural drugs—Rhizoma Drynariae (RD) and Lycii Fructus (LF)—for case analysis. The study found that RD primarily improves symptoms such as indigestion, constipation, fatigue, polyuria, and depression, while LF significantly ameliorates symptoms related to the nervous and muscular systems, such as hoarseness, dizziness, vertigo, and fever symptoms. This analysis successfully differentiated two groups of symptoms and precisely constructed a logical chain among “natural Medicines-molecular tArGets-Illness-symptom Clusters” (MAGIC chain) achieving a refined classification of OP. The results of this study support the effectiveness of implementing personalized medical strategies in the treatment of OP, providing a scientific basis for the clinical application of natural medicines and patient self-management. |
| format | Article |
| id | doaj-art-4ce5131349a742e69f5ba526662e3dbb |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-4ce5131349a742e69f5ba526662e3dbb2025-08-20T02:49:34ZengNature PortfolioScientific Reports2045-23222025-03-0115111410.1038/s41598-025-95304-3Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clustersYili Zhang0Xiangyun Guo1Kai Sun2Liang Wang3Siyuan Huang4Yiwen Gan5Jinran Qin6Qingqing Liu7Yan Li8Zikai Jin9Liguo Zhu10Xu Wei11School of Integrated Chinese and Western Medicine, Nanjing University of Chinese MedicineSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese MedicineWangjing Hospital, China Academy of Chinese Medical SciencesSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese MedicineDepartment of Biochemistry, University of OxfordSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese MedicineSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese MedicineSchool of Integrated Chinese and Western Medicine, Nanjing University of Chinese MedicineWangjing Hospital, China Academy of Chinese Medical SciencesWangjing Hospital, China Academy of Chinese Medical SciencesWangjing Hospital, China Academy of Chinese Medical SciencesWangjing Hospital, China Academy of Chinese Medical SciencesAbstract Osteoporosis (OP) is a metabolic bone disease characterized by reduced bone density and fragility, impairing quality of life. Traditional treatments often overlook symptoms like back and joint pain, increasing burden. This study aims to map relationships between natural medicines, targets, and symptom clusters, demonstrating their effectiveness in personalized OP treatment to enhance clinical strategies and self-assessment. We used compounds and targets, applying Summary data-based Mendelian Randomisation (SMR) analysis for biological process and molecular function enrichment. Additionally, we employed Phenome-Wide Association Studies (PheWAS) to select two natural drugs—Rhizoma Drynariae (RD) and Lycii Fructus (LF)—for case analysis. The study found that RD primarily improves symptoms such as indigestion, constipation, fatigue, polyuria, and depression, while LF significantly ameliorates symptoms related to the nervous and muscular systems, such as hoarseness, dizziness, vertigo, and fever symptoms. This analysis successfully differentiated two groups of symptoms and precisely constructed a logical chain among “natural Medicines-molecular tArGets-Illness-symptom Clusters” (MAGIC chain) achieving a refined classification of OP. The results of this study support the effectiveness of implementing personalized medical strategies in the treatment of OP, providing a scientific basis for the clinical application of natural medicines and patient self-management.https://doi.org/10.1038/s41598-025-95304-3Natural medicinesMolecular targetsIllnessSymptom clustersOsteoporosis |
| spellingShingle | Yili Zhang Xiangyun Guo Kai Sun Liang Wang Siyuan Huang Yiwen Gan Jinran Qin Qingqing Liu Yan Li Zikai Jin Liguo Zhu Xu Wei Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters Scientific Reports Natural medicines Molecular targets Illness Symptom clusters Osteoporosis |
| title | Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters |
| title_full | Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters |
| title_fullStr | Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters |
| title_full_unstemmed | Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters |
| title_short | Exploring the classification and treatment of osteoporosis from the perspectives of natural medicines, molecular targets, and symptom clusters |
| title_sort | exploring the classification and treatment of osteoporosis from the perspectives of natural medicines molecular targets and symptom clusters |
| topic | Natural medicines Molecular targets Illness Symptom clusters Osteoporosis |
| url | https://doi.org/10.1038/s41598-025-95304-3 |
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