Integrated UPLC–MS/MS and UPLC–Q–TOF–MS/MS analysis to reveal pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine in rats

Integrated UPLC–MS/MS and UPLC–Q–TOF–MS/MS analysis to reveal pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine in rats

Background and ObjectiveFritillaria Bulbus is a traditional Chinese medicine used to treat respiratory diseases such as cough, expectoration, and asthma for more than 2000 years. Sipeimine, a major isosteroidal alkaloid isolated from Fritillaria Bulbus, has attracted considerable attention from the...

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Bibliographic Details
Main Authors: Hui Zong, Chongyang Wang, Dongdong He, Liting Liu, Juanjuan Wan, Guodong Wang, Dingtao Li, Jun Ran, Meiling Zhang, Hui Tang, Liping Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
sipeimine
pharmacokinetics
tissue distribution
metabolism
excretion
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1595731/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1595731/full

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