Bidirectional Mendelian randomization analysis and systematic meta-analysis of causal relationships between hepatocellular carcinoma and non-alcoholic fatty liver disease

Bidirectional Mendelian randomization analysis and systematic meta-analysis of causal relationships between hepatocellular carcinoma and non-alcoholic fatty liver disease

Abstract Background The causal relationships between hepatocellular carcinoma (HCC) and non-alcoholic fatty liver disease (NAFLD) remain unclear. This study investigated bidirectional causality between HCC and NAFLD using Mendelian randomization, and evaluated liver-related mortality risk in NAFLD p...

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Bibliographic Details
Main Authors: Tielong Zhao, Yanglieguang Lou
Format: Article
Language:English
Published: Springer 2025-08-01
Series:Discover Oncology
Subjects:
Hepatocellular carcinoma
Non-alcoholic fatty liver disease
Mendelian randomization
Meta-analysis
Liver-related mortality
Online Access:https://doi.org/10.1007/s12672-025-03350-0
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https://doi.org/10.1007/s12672-025-03350-0

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