Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice

Effect of dolutegravir-based antiretroviral therapy on glycemic control in female mice

Abstract Dolutegravir (DTG), is recommended for all people with HIV, including pregnant women. Weight gain and hyperglycemia have been reported with DTG use, as well as a signal for neural tube defects (NTDs) that has waned over time. Obesity and hyperglycemia are risk factors for NTDs. We explored...

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Bibliographic Details
Main Authors: Valeriya Dontsova, Haneesha Mohan, Audrey Yee, Jessica Nguyen, Maisha Fahmida, Nicholas D. E. Greene, Andrew J. Copp, Rebecca Zash, Jennifer Jao, Lena Serghides
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
INSTI
Hyperglycemia
Leptin
Cortisol
Lipogenesis
Neural tube defects
Online Access:https://doi.org/10.1038/s41598-025-02130-8
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https://doi.org/10.1038/s41598-025-02130-8

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