Efficacy of Ceftobiprole and Daptomycin at Bone Concentrations Against Methicillin-Resistant <i>Staphylococcus aureus</i> Biofilm: Results of a Dynamic In Vitro PK/PD Model

Efficacy of Ceftobiprole and Daptomycin at Bone Concentrations Against Methicillin-Resistant <i>Staphylococcus aureus</i> Biofilm: Results of a Dynamic In Vitro PK/PD Model

<b>Background</b>: The presence of biofilms and low antimicrobial concentrations in bone tissue make prosthetic joint infections (PJI) difficult to treat. Ceftobiprole (CTO) has a potential role in MRSA PJI. This study evaluated the efficacy of ceftobiprole and daptomycin (DAP) alone and...

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Bibliographic Details
Main Authors: Mikel Mancheño-Losa, María Ángeles Meléndez-Carmona, Carlos Lumbreras, Jaime Lora-Tamayo
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Antibiotics
Subjects:
biofilm
MRSA
prosthetic joint infection
ceftobiprole
daptomycin
Online Access:https://www.mdpi.com/2079-6382/14/4/386
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