XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tumor Cells

XMU-MP-1, Inhibitor of STE20-like MST1/2 Kinases of the Hippo Signaling Pathway, Suppresses the Cell Cycle, Activates Apoptosis and Autophagy, and Induces Death of Hematopoietic Tumor Cells

<b>Background/Objectives</b>: Currently, there is limited knowledge on the molecular mechanisms of the “non-canonical” Hippo signaling pathway in hematopoietic tumor cells. We have shown that targeting the MST1/2 kinases, which are the key molecules in this signaling pathway, may be an e...

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Bibliographic Details
Main Authors: Alexander G. Stepchenko, Sofia G. Georgieva, Elizaveta V. Pankratova
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
MST1/2 kinases inhibitor
hematopoietic tumors
programmed cell death
XMU-MP-1
cell cycle
cancer resistance
Online Access:https://www.mdpi.com/1424-8247/18/6/874
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