Altered CD4 T cell response in oligometatastic non-small cell lung cancer brain metastasis

Altered CD4 T cell response in oligometatastic non-small cell lung cancer brain metastasis

Abstract Lung cancer is the leading cause of cancer mortality globally, with brain metastasis (BM) in 40% of advanced non-small-cell lung cancer (NSCLC) cases. In 15% of these cases, the brain is the sole affected organ (oligometastasis), which correlates with a better prognosis compared to widespre...

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Main Authors: Mais Alsousli, Cecile L. Maire, Andras Piffko, Jakob Matschke, Laura Glau, Merle Reetz, Svenja Schneegans, Gresa Emurlai, Benedikt Asey, Alessandra Rünger, Sven Peine, Jolanthe Kropidlowski, Jens Gempt, Markus Glatzel, Manfred Westphal, Eva Tolosa, Katrin Lamszus, Klaus Pantel, Simon A. Joosse, Malte Mohme, Harriet Wikman
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
NSCLC
Brain metastasis
Immunophenotyping
T cells
CD4
Online Access:https://doi.org/10.1186/s40478-025-02011-1
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https://doi.org/10.1186/s40478-025-02011-1

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