Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening

IntroductionData-driven omics approaches have rapidly advanced our understanding of the molecular heterogeneity of Alzheimer’s disease (AD). However, limited by the unavailability of brain tissue, there is an urgent need for a non-invasive tool to detect alterations in the AD brain. Cell-free RNA (c...

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Bibliographic Details
Main Authors: Li Wu, Renxin Zhang, Yichao Wang, Shaoxing Dai, Naixue Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
cell-free RNA
single-cell RNA-seq
machine learning
non-invasive early screening
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1571783/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2025.1571783/full

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