Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy

Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy

Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease arising from accumulation of the α-synuclein and aberrant protein clearance in oligodendrocytes. The mechanisms of autophagy involved in the progression of MSA remain poorly understood. It is reported that MSA patients...

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Main Authors: Huanzhu Liu, Ruoyang Yu, Muwei Zhang, Xiaoyan Zheng, Lizi Zhong, Wanlin Yang, Yuqi Luo, Zifeng Huang, Jialing Zheng, Hui Zhong, Xiaobo Wei, Wenhua Zheng, Yinghua Yu, Qing Wang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurotherapeutics
Subjects:
Multiple system atrophy
Oligodendrocyte
Fibrinogen
Fibrinogen degradation products
Autophagy
Beclin1
Online Access:http://www.sciencedirect.com/science/article/pii/S1878747925000169
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