Application and mechanism of anticancer peptides in organoid models of intrahepatic cholangiocarcinoma

Application and mechanism of anticancer peptides in organoid models of intrahepatic cholangiocarcinoma

Abstract The clinical manifestations of intrahepatic cholangiocarcinoma (ICC) are non-specific, and few patients qualify for surgical resection at diagnosis, thus limiting treatment options. Anticancer peptides (ACPs) exhibit potent tumour inhibition, minimal side effects, easy modification, and low...

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Main Authors: Xuekai Hu, Yue Zhang, Yanchen Li, Qiuxia Zheng, Haixia Zhao, Yun Zhang, Jingman Ni, Jia Yao
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Intrahepatic cholangiocarcinoma
Patient-derived organoid
Anticancer peptide
Disruption of cell membrane
Apoptosis
Online Access:https://doi.org/10.1038/s41598-025-06127-1
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https://doi.org/10.1038/s41598-025-06127-1

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