Proapoptotic role of CDK1 in overcoming paclitaxel resistance in ovarian cancer cells in response to combined treatment with paclitaxel and duloxetine

Proapoptotic role of CDK1 in overcoming paclitaxel resistance in ovarian cancer cells in response to combined treatment with paclitaxel and duloxetine

Abstract Background Paclitaxel resistance and recurrence are major obstacles in ovarian cancer, which is the leading cause of death among gynecologic cancers. During cancer cell progression, cyclin-dependent kinase 1 (CDK1) drives cells through the G2 phase and into mitosis. In this study, we demons...

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Main Authors: Gyeongmi Kim, Se-Kyeong Jang, Se Hee Ahn, Selim Kim, Chan Sub Park, Min-Ki Seong, Hyun-Ah Kim, Seunghee Bae, Jae Ho Lee, Hyunggee Kim, Hyeon-Ok Jin, In-Chul Park
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cancer Cell International
Subjects:
Apoptosis
Bcl-2
CDK1
Duloxetine
mTORC1/S6K
Ovarian cancer
Online Access:https://doi.org/10.1186/s12935-024-03607-8
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https://doi.org/10.1186/s12935-024-03607-8

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