uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

Abstract High intratumoral levels of urokinase‐type plasminogen activator (uPA)‐plasminogen activator inhibitor‐1 (PAI‐1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protein complex remains obscure. Here, we demonstrate that heter...

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Main Authors: Bernd Uhl, Laura A Mittmann, Julian Dominik, Roman Hennel, Bojan Smiljanov, Florian Haring, Johanna B Schaubächer, Constanze Braun, Lena Padovan, Robert Pick, Martin Canis, Christian Schulz, Matthias Mack, Ewgenija Gutjahr, Peter Sinn, Jörg Heil, Katja Steiger, Sandip M Kanse, Wilko Weichert, Markus Sperandio, Kirsten Lauber, Fritz Krombach, Christoph A Reichel
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
biomarker
breast cancer
fibrinolysis
innate immunity
neutrophils
Online Access:https://doi.org/10.15252/emmm.202013110
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https://doi.org/10.15252/emmm.202013110

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