Gene expression changes in human cerebral arteries following hemoglobin exposure: implications for vascular responses in SAH

Gene expression changes in human cerebral arteries following hemoglobin exposure: implications for vascular responses in SAH

Subarachnoid hemorrhage (SAH), characterized by the presence of hemoglobin (Hb) in the subarachnoid space, significantly impacts cerebral vessels, leading to various pathological outcomes. The toxicity of cell-free Hb released from erythrocytes and its metabolites after SAH causes vasoconstriction a...

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Bibliographic Details
Main Authors: Chathathayil M. Shafeeque, Arif O. Harmanci, Sithara Thomas, Ari C. Dienel, Devin W. McBride, Kumar T. Peeyush, Spiros L. Blackburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Physiology
Subjects:
brain vessels
cerebral arteries
hemoglobin
subarachnoid hemorrhage
vascular injury
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2025.1529113/full
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https://www.frontiersin.org/articles/10.3389/fphys.2025.1529113/full

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