Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols

Differences in neuronal ciliation rate and ciliary content revealed by systematic imaging-based analysis of hiPSC-derived models across protocols

IntroductionCiliopathies are a group of human Mendelian disorders caused by dysfunction of primary cilia, small quasi-ubiquitous sensory organelles. Patients suffering from ciliopathies often display prominent neurodevelopmental phenotypes, underscoring the importance of primary cilia during develop...

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Main Authors: Walther Haenseler, Melanie Eschment, Beth Evans, Marta Brasili, Joana Figueiro-Silva, Fee Roethlisberger, Affef Abidi, Darcie Jackson, Martin Müller, Sally A. Cowley, Ruxandra Bachmann-Gagescu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cilia
human iPSC (induced pluripotent stem cells)
neurons
ciliopathies
immunofluorescence staining
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1516596/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1516596/full

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