Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections
Abstract Periodontitis is a chronic inflammatory disease initiated by plaque microorganisms, with the regulatory mechanisms of its progression being a primary research focus. Ferroptosis, a unique form of cell death driven by iron-dependent lipid peroxidation, has been increasingly recognized for it...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2025-06-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-025-02550-5 |
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| _version_ | 1850113159051870208 |
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| author | Peng Guan Qijun Ruan Jiatong Li Mengying Xi Weijuan Qi Kang I. Ko Jia Ni |
| author_facet | Peng Guan Qijun Ruan Jiatong Li Mengying Xi Weijuan Qi Kang I. Ko Jia Ni |
| author_sort | Peng Guan |
| collection | DOAJ |
| description | Abstract Periodontitis is a chronic inflammatory disease initiated by plaque microorganisms, with the regulatory mechanisms of its progression being a primary research focus. Ferroptosis, a unique form of cell death driven by iron-dependent lipid peroxidation, has been increasingly recognized for its crucial role in modulating chronic inflammation. This study focused on the molecular mechanisms by which plaque microorganisms and the inflammatory microenvironment trigger ferroptosis in periodontal cells, elucidating how ferroptosis in these cells promotes periodontitis progression. Additionally, the potential exacerbation of periodontitis through ferroptosis in systemic diseases such as Alzheimer’s disease, nonalcoholic steatohepatitis, chronic obstructive pulmonary disease, and type 2 diabetes is discussed. This review aims to provide new theoretical foundations and strategies for the treatment of periodontitis. |
| format | Article |
| id | doaj-art-4c5350b02f9e4c458d77bf0a29974464 |
| institution | OA Journals |
| issn | 2058-7716 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj-art-4c5350b02f9e4c458d77bf0a299744642025-08-20T02:37:13ZengNature Publishing GroupCell Death Discovery2058-77162025-06-0111111210.1038/s41420-025-02550-5Ferroptosis in periodontitis: mechanisms, impacts, and systemic connectionsPeng Guan0Qijun Ruan1Jiatong Li2Mengying Xi3Weijuan Qi4Kang I. Ko5Jia Ni6Department of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical UniversityCenter of Stomatology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang UniversityDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical UniversityDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical UniversityDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical UniversityDepartment of Periodontics, School of Dental Medicine, University of PennsylvaniaDepartment of Periodontics, Stomatological Hospital, School of Stomatology, Southern Medical UniversityAbstract Periodontitis is a chronic inflammatory disease initiated by plaque microorganisms, with the regulatory mechanisms of its progression being a primary research focus. Ferroptosis, a unique form of cell death driven by iron-dependent lipid peroxidation, has been increasingly recognized for its crucial role in modulating chronic inflammation. This study focused on the molecular mechanisms by which plaque microorganisms and the inflammatory microenvironment trigger ferroptosis in periodontal cells, elucidating how ferroptosis in these cells promotes periodontitis progression. Additionally, the potential exacerbation of periodontitis through ferroptosis in systemic diseases such as Alzheimer’s disease, nonalcoholic steatohepatitis, chronic obstructive pulmonary disease, and type 2 diabetes is discussed. This review aims to provide new theoretical foundations and strategies for the treatment of periodontitis.https://doi.org/10.1038/s41420-025-02550-5 |
| spellingShingle | Peng Guan Qijun Ruan Jiatong Li Mengying Xi Weijuan Qi Kang I. Ko Jia Ni Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections Cell Death Discovery |
| title | Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections |
| title_full | Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections |
| title_fullStr | Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections |
| title_full_unstemmed | Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections |
| title_short | Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections |
| title_sort | ferroptosis in periodontitis mechanisms impacts and systemic connections |
| url | https://doi.org/10.1038/s41420-025-02550-5 |
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