Sinularin induces autophagy-dependent cell death by activating ULK1 and enhancing FOXO3-ATG4A axis in prostate cancer cells

Sinularin induces autophagy-dependent cell death by activating ULK1 and enhancing FOXO3-ATG4A axis in prostate cancer cells

Abstract Sinularin is a natural product extracted from soft coral and is shown to exhibit antitumor effects against multiple human cancers. We previously showed that Sinularin induces apoptotic cell death via stabilizing the FOXO3 protein in prostate cancer cells. In this study, we demonstrated that...

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Bibliographic Details
Main Authors: Xiang-yu Meng, Yi Li, Ze-jun Yan, Sha-zhou Ye, Ke-jie Wang, Jun-feng Chen, Rui Yu, Qi Ma
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Sinularin
Prostate cancer
Autophagy
Apoptosis
FOXO3
Online Access:https://doi.org/10.1038/s41598-025-00909-3
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https://doi.org/10.1038/s41598-025-00909-3

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