A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants

A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants

Abstract Pseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity. We constructed a self-amplifying mRNA (saRNA) vaccine...

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Main Authors: Tong Ling, Zhang Xin, Li Huan-huan, Zheng Ya-ting, Liu Ya-mei, Guo Rong-li, Armando Mario Damiani, Chen Sai-sai, Zhang Chuan-jian, Duan Rui, Mao Shu-yu, Yu Jia-li, Zhang Qian-qian, Tao Ruo-nan, Nikolaus Osterrieder, Xia Shu-hua, Wang Ji-chun
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01251-5
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https://doi.org/10.1038/s41541-025-01251-5

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