S-adenosylmethionine addiction confers sensitivity to methionine restriction in <i>KMT2A</i>-rearranged acute lymphoblastic leukemia

S-adenosylmethionine addiction confers sensitivity to methionine restriction in <i>KMT2A</i>-rearranged acute lymphoblastic leukemia

Current intensive chemotherapy regimens have improved overall survival in pediatric acute lymphoblastic leukemia (ALL) but fail to cure some high-risk patient subgroups. We observed that lysine methyltransferase 2A (KMT2A)-rearranged leukemia, an aggressive subset with a dismal prognosis, is partic...

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Main Authors: Trisha Tee, Titine J.J. Ruiter, Shuiyan Wu, Weiya Zhang, Dorette van Ingen Schenau, Maria Rodionova, Danique Wajon, Britt M.T. Vervoort, Kari J.T. Grunewald, Marjolein Bosma, Rico Hagelaar, John Baker-Hernandez, Ahmed Dahaoui, Pauline Schneider, Nanda M. Verhoeven-Duif, Laurens T. van der Meer, Frank N. van Leeuwen
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-04-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12034
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https://haematologica.org/article/view/12034

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