Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

Mapping hippocampal glutamate in healthy aging with in vivo glutamate-weighted CEST (GluCEST) imaging

IntroductionHippocampal glutamate (Glu) dysfunction is a pertinent indicator of neurodegeneration, yet mapping typical age-related changes in Glu has been challenging. Here, we use a 7T MRI approach, Glutamate Chemical Exchange Saturation Transfer (GluCEST), to measure bilateral hippocampal Glu in h...

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Bibliographic Details
Main Authors: Maggie K. Pecsok, Heather Robinson, Ally Atkins, Monica E. Calkins, Mark A. Elliott, Arianna Mordy, Jacquelyn Stifelman, Ruben C. Gur, Paul J. Moberg, Ravi Prakash Reddy Nanga, Kosha Ruparel, Russell T. Shinohara, David A. Wolk, Ravinder Reddy, David R. Roalf
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
glutamate
aging
7Tesla MRI
GluCEST
hippocampus
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1535158/full
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