Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat modelCentral MessagePerspective

Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat modelCentral MessagePerspective

Objective: To test the safety and efficacy of combination treatment for pleural mesothelioma (PM) with intracavitary cisplatin-fibrin (cis-fib) plus hemithoracic irradiation (IR) applied after lung-sparing surgery in an orthotopic immunocompetent rat model. Methods: We randomized male F344 rats into...

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Main Authors: Michaela B. Kirschner, PhD, Mayura Meerang, PhD, Vanessa Orlowski, Katarzyna Furrer, MD, Fabienne Tschanz, PhD, Ivo Grgic, PhD, Virginia Cecconi, PhD, Maries van den Broek, PhD, Matthias Guckenberger, MD, Martin Pruschy, MD, Olivia Lauk, MD, Isabelle Opitz, MD
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:JTCVS Open
Subjects:
pleural mesothelioma
intracavitary therapy
chemotherapy
radiotherapy
radiosensitization
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273624002419
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