Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma

Repurposed genipin targeting UCP2 exhibits antitumor activity through inducing ferroptosis in glioblastoma

Uncoupling protein-2 (UCP2) controls the antioxidant response and redox homeostasis in cancer and is considered a potent molecular target for cancer treatment. However, the specific mechanism of UCP2 inhibition and its role in glioblastoma...

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Bibliographic Details
Main Authors: Dong Hao, Sun Kaixuan, Wang Xuejie, Cui Meimei, Ma Yaping, Li Kexin, Duan Wanli, Zhang Hongxing, Zhang Liying, Sheng Zhimei, He Maotao, Zhang Baogang
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2024-11-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
genipin
uncoupling protein-2
ferroptosis
glioblastoma
malignant behavior of tumors
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2024168
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https://www.sciengine.com/doi/10.3724/abbs.2024168

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