Spatial distribution of Plasmodium vivax Duffy Binding Protein copy number variation and Duffy genotype, and their association with parasitemia in Ethiopia.

Spatial distribution of Plasmodium vivax Duffy Binding Protein copy number variation and Duffy genotype, and their association with parasitemia in Ethiopia.

<h4>Background</h4>Duffy Binding Protein (PvDBP) binding to the Duffy antigen receptor for chemokine (DARC) is essential for Plasmodium vivax invasion of human reticulocytes. PvDBP copy number variation (CNV) might increase parasite invasion and thus parasitemia. We examined the spatial...

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Main Authors: Yasin Nasir, Eshetu Molla, Getnet Habtamu, Solomon Sisay, Legesse Alamerie Ejigu, Fikregabrail Aberra Kassa, Mulugeta Demisse, Wakweya Chali, Melat Abdo, Dawit Hailu Alemayehu, Lina Alemayehu, Alemayehu Letebo, Tadele Emiru, Jimma Dinsa Deressa, Tajudin Abdurhaman Hamza, Abel Beliyu Tamirat, Tadesse Misganaw, Alayu Bogale, Zufan Yiheyis Abriham, Sisay Dugassa, Migbaru Keffale, Fekadu Massebo, Hassen Mamo, Endalamaw Gadisa, Chris Drakeley, Alemayehu Godana Birhanu, Cristian Koepfli, Fitsum G Tadesse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-02-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0012837
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https://doi.org/10.1371/journal.pntd.0012837

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