Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

Cntnap2 loss drives striatal neuron hyperexcitability and behavioral inflexibility

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by two major diagnostic criteria – persistent deficits in social communication and interaction, and the presence of restricted, repetitive patterns of behavior (RRBs). Evidence from both human and animal model studies of A...

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Bibliographic Details
Main Authors: Katherine R Cording, Emilie M Tu, Hongli Wang, Alexander HCW Agopyan-Miu, Helen S Bateup
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
Cntnap2
Caspr2
striatum
cognitive flexiblity
neurodevelopmental disorders
autism spectrum disorder
Online Access:https://elifesciences.org/articles/100162
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https://elifesciences.org/articles/100162

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