Construction of TRIF-knockout NA and BHK-21 cell lines and effect on rabies virus proliferation efficiency

Construction of TRIF-knockout NA and BHK-21 cell lines and effect on rabies virus proliferation efficiency

ObjectiveTo construct TIR-domain-containing adaptor-inducing interferon β (TRIF) gene knockout mouse NA cell line and hamster BHK-21 cell line using CRISPR/Cas9 technology, evaluate the proliferative capacity of rabies virus (RABV) in these knockout cell lines, and investigate TRIF function during R...

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Bibliographic Details
Main Authors: Weitao HUANG, Jiaqi LI, Yao PENG, Xiangping YIN, Xiaofeng GUO, Jun LUO
Format: Article
Language:zho
Published: South China Agricultural University 2025-09-01
Series:Huanan Nongye Daxue xuebao
Subjects:
crispr/cas9
tir-domain-containing adapter-inducing interferon β gene
gene knockout
rabies virus
Online Access:https://journal.scau.edu.cn/article/doi/10.7671/j.issn.1001-411X.202502016
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https://journal.scau.edu.cn/article/doi/10.7671/j.issn.1001-411X.202502016

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