On Programmed Cell Death in Plasmodium falciparum: Status Quo
Conflicting arguments and results exist regarding the occurrence and phenotype of programmed cell death (PCD) in the malaria parasite Plasmodium falciparum. Inconsistencies relate mainly to the number and type of PCD markers assessed and the different methodologies used in the studies. In this paper...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/646534 |
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| _version_ | 1832549790858084352 |
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| author | Dewaldt Engelbrecht Pierre Marcel Durand Thérèsa Louise Coetzer |
| author_facet | Dewaldt Engelbrecht Pierre Marcel Durand Thérèsa Louise Coetzer |
| author_sort | Dewaldt Engelbrecht |
| collection | DOAJ |
| description | Conflicting arguments and results exist regarding the occurrence and phenotype of programmed cell death (PCD) in the malaria parasite Plasmodium falciparum. Inconsistencies relate mainly to the number and type of PCD markers assessed and the different methodologies used in the studies. In this paper, we provide a comprehensive overview of the current state of knowledge and empirical evidence for PCD in the intraerythrocytic stages of P. falciparum. We consider possible reasons for discrepancies in the data and offer suggestions towards more standardised investigation methods in this field. Furthermore, we present genomic evidence for PCD machinery in P. falciparum. We discuss the potential adaptive or nonadaptive role of PCD in the parasite life cycle and its possible exploitation in the development of novel drug targets. Lastly, we pose pertinent unanswered questions concerning the PCD phenomenon in P. falciparum to provide future direction. |
| format | Article |
| id | doaj-art-4bc779871c934938b77af76232c19183 |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-4bc779871c934938b77af76232c191832025-02-03T06:08:29ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/646534646534On Programmed Cell Death in Plasmodium falciparum: Status QuoDewaldt Engelbrecht0Pierre Marcel Durand1Thérèsa Louise Coetzer2Plasmodium Molecular Research Unit, Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South AfricaPlasmodium Molecular Research Unit, Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South AfricaPlasmodium Molecular Research Unit, Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South AfricaConflicting arguments and results exist regarding the occurrence and phenotype of programmed cell death (PCD) in the malaria parasite Plasmodium falciparum. Inconsistencies relate mainly to the number and type of PCD markers assessed and the different methodologies used in the studies. In this paper, we provide a comprehensive overview of the current state of knowledge and empirical evidence for PCD in the intraerythrocytic stages of P. falciparum. We consider possible reasons for discrepancies in the data and offer suggestions towards more standardised investigation methods in this field. Furthermore, we present genomic evidence for PCD machinery in P. falciparum. We discuss the potential adaptive or nonadaptive role of PCD in the parasite life cycle and its possible exploitation in the development of novel drug targets. Lastly, we pose pertinent unanswered questions concerning the PCD phenomenon in P. falciparum to provide future direction.http://dx.doi.org/10.1155/2012/646534 |
| spellingShingle | Dewaldt Engelbrecht Pierre Marcel Durand Thérèsa Louise Coetzer On Programmed Cell Death in Plasmodium falciparum: Status Quo Journal of Tropical Medicine |
| title | On Programmed Cell Death in Plasmodium falciparum: Status Quo |
| title_full | On Programmed Cell Death in Plasmodium falciparum: Status Quo |
| title_fullStr | On Programmed Cell Death in Plasmodium falciparum: Status Quo |
| title_full_unstemmed | On Programmed Cell Death in Plasmodium falciparum: Status Quo |
| title_short | On Programmed Cell Death in Plasmodium falciparum: Status Quo |
| title_sort | on programmed cell death in plasmodium falciparum status quo |
| url | http://dx.doi.org/10.1155/2012/646534 |
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