Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia

Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia

Abstract BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leukemia (CML) over the past decades. In this study, we reported an unexpected role of neddylation inhibitors in desensitizing the therapeutic efficacy of BCR::ABL1-targeting TKIs in CML. Unlike...

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Bibliographic Details
Main Authors: Congyi Zhang, Yikai Yao, Qiuting Qian, Xiongyu Han, Yunkun Lu, Xinyi Jiang, Hongqiang Cheng, Xue Zhang, Ying Chi, Yuehai Ke, Peng Xiao
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Chronic myeloid leukemia
Tyrosine kinase inhibitor
Neddylation
Post-translational modification
Resistance
Online Access:https://doi.org/10.1038/s41598-025-04153-7
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https://doi.org/10.1038/s41598-025-04153-7

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