NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway

NMN reverses D-galactose-induced neurodegeneration and enhances the intestinal barrier of mice by activating the Sirt1 pathway

BackgroundAge-related decline in nicotinamide adenine dinucleotide (NAD+)—a central regulator of cellular metabolism, DNA repair, and immune homeostasis—is strongly associated with physiological dysfunction. Nicotinamide mononucleotide (NMN), a potent NAD+ precursor, shows promise in counteracting a...

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Bibliographic Details
Main Authors: Yuxian Lin, Yajing Wang, Xinxin Yang, Ziwei Ding, Mingye Hu, Xianfeng Huang, Qichun Zhang, Yingcong Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
aging
NMN
oxidative stress
neuroinflammation
intestinal barrier
SIRT1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1545585/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1545585/full

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