House dust mites stimulate thymic stromal lymphopoietin production in human bronchial epithelial cells and promote airway remodeling through activation of PAR2 and ERK signaling pathway

House dust mites stimulate thymic stromal lymphopoietin production in human bronchial epithelial cells and promote airway remodeling through activation of PAR2 and ERK signaling pathway

Abstract House dust mites (HDM) are common aeroallergens linked to airway inflammation and remodeling in asthma. Protease-activated receptor 2 (PAR2) and thymic stromal lymphopoietin (TSLP) may mediate these immune responses. However, how the epithelium influences fibroblasts toward airway remodelin...

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Bibliographic Details
Main Authors: Yi-An Hsieh, Yi-Han Hsiao, Hsin-Kuo Ko, Yi-Luen Shen, Chien-Wen Huang, Diahn-Warng Perng, Kang-Cheng Su
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Airway inflammation
House dust mite
Protease-activated receptor 2
Remodeling
Thymic stromal lymphopoietin
Online Access:https://doi.org/10.1038/s41598-024-79226-0
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https://doi.org/10.1038/s41598-024-79226-0

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