NAD+ homeostasis in human health and disease

Abstract Depletion of nicotinamide adenine dinucleotide (NAD+), a central redox cofactor and the substrate of key metabolic enzymes, is the causative factor of a number of inherited and acquired diseases in humans. Primary deficiencies of NAD+ homeostasis are the result of impaired biosynthesis, whi...

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Bibliographic Details
Main Authors: Rubén Zapata‐Pérez, Ronald J A Wanders, Clara D M van Karnebeek, Riekelt H Houtkooper
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
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Online Access:https://doi.org/10.15252/emmm.202113943
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