Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease

Impact of noradrenergic inhibition on neuroinflammation and pathophysiology in mouse models of Alzheimer’s disease

Abstract Norepinephrine (NE) modulates cognitive function, arousal, attention, and responses to novelty and stress, and it also regulates neuroinflammation. We previously demonstrated behavioral and immunomodulatory effects of beta-adrenergic pharmacology in mouse models of Alzheimer’s disease (AD)....

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Main Authors: Andrew K. Evans, Heui Hye Park, Claire E. Woods, Rachel K. Lam, Daniel Ryskamp Rijsketic, Christine Xu, Emily K. Chu, Peter Ciari, Sarah Blumenfeld, Laura M. Vidano, Nay Lui Saw, Boris D. Heifets, Mehrdad Shamloo
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s Disease
Norepinephrine
Locus coeruleus
Beta-adrenergic receptor
Beta-blocker
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03306-1
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https://doi.org/10.1186/s12974-024-03306-1

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