Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

Essential role of proline synthesis and the one-carbon metabolism pathways for systemic virulence of Streptococcus pneumoniae

ABSTRACT Virulence screens have indicated potential roles during Streptococcus pneumoniae infection for the one-carbon metabolism pathway component Fhs and proline synthesis mediated by ProABC. To define how these metabolic pathways affect S. pneumoniae virulence, we have investigated the phenotypes...

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Main Authors: Elisa Ramos-Sevillano, Giuseppe Ercoli, Modupeh Betts, José Afonso Guerra-Assunção, Amy Iverson, Matthew Frank, Frederick Partridge, Stephanie W. Lo, Vitor E. Fernandes, Fauzy Nasher, Emma Wall, Brendan Wren, Stephen B. Gordon, Daniela M. Ferreira, Rob Heyderman, Jason Rosch, Jeremy S. Brown
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mBio
Subjects:
Streptococcus pneumoniae
proline synthesis
formate-tetrahydrofolate ligase
stringent response
virulence
Online Access:https://journals.asm.org/doi/10.1128/mbio.01758-24
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https://journals.asm.org/doi/10.1128/mbio.01758-24

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