Disruption of small intestinal mucosal homeostasis in mice with amiodarone induced steatohepatitis

Disruption of small intestinal mucosal homeostasis in mice with amiodarone induced steatohepatitis

Abstract In the current study, we sought to investigate the pathogenesis of amiodarone (AMD)-induced steatohepatitis, focusing on the pathological changes in the small intestine and liver. The association between patients taking AMD and metabolic dysfunction-associated steatohepatitis (MASH) was ana...

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Bibliographic Details
Main Authors: Shoji Kawauchi, Sayo Horibe, Toru Tanaka, Naoto Sasaki, Junichi Kunimasa, Yoshiyuki Rikitake
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Drug-induced MASH
Gut–liver axis
Intestinal microbiota
Wnt/β-catenin signaling pathway
JADER
Online Access:https://doi.org/10.1038/s41598-025-04680-3
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https://doi.org/10.1038/s41598-025-04680-3

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