Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer

Intravesical delivery of mucoadhesive and tumor-selective-penetrating nanozymes for enhancing the PDT of bladder cancer

Abstract Intravesical photodynamic therapy (PDT) emerges as a promising modality for bladder cancer treatment, yet its efficacy is often curtailed by weak muco-adhesion, poor muco-penetration, low tumor-targeting and intra-tumoral oxygen scarcity. In this work, we introduce a drug delivery system le...

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Main Authors: Yang Liu, Wentao Xu, Xiaowen Qin, Jiajia Zheng, Bin Zheng, Li Sun, Wenyan Zuo, Dingyi Liu, Zhenghong Liu, Yixuan Mou, Heng Wang, Qi Zhang, Jun Chen, Pu Zhang, Dahong Zhang
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
Bladder Cancer
Intravesical therapy
Nanozyme
Photodynamic therapy
Online Access:https://doi.org/10.1186/s12951-025-03594-6
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https://doi.org/10.1186/s12951-025-03594-6

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