NDP52 deficiency accelerates chondrocyte degeneration through promoting pathogenic mitochondrial ROS via reverse electron transport

NDP52 deficiency accelerates chondrocyte degeneration through promoting pathogenic mitochondrial ROS via reverse electron transport

NDP52, a constituent of the selective autophagy receptors (SARs), was recognized for its involvement in facilitating substrate degradation via autophagic bridging. However, its autonomous function apart from autophagy remained largely unexplored. Here, we reported that NDP52 was down-regulated in de...

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Bibliographic Details
Main Authors: Yutao Zhu, Yaohan Xu, Dinqi Xie, Nengfeng Yu, Jiaxin Chen, Jiechao Xia, Zixuan Mei, Yang Jin, Chuan Hu, Pan Tang, Sicheng Jiang, Chao Jiang, Honghai Song, Zhijun Hu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
Osteoarthritis
Chondrocyte
NDP52
Mitochondria reactive oxygen species (mtROS)
Reverse electron transport (RET)
MTIF3
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002605
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